Professor and Constellation Endowed Chair
The unique strengths of our laboratory involve development of NMR methods and software for analysis of protein structures and dynamics, and in applying these methods in structure-function studies. As Director of the NIGMS-funded Northeast Structural Genomics Consortium (NESG) for 16 years (2000 – 2016), our lab lead a team that determined more than 1,200 3D structures by X-ray crystallography and NMR methods. Over the course of this project we developed expertise in protein expression and crystallization, and in reconstitution and structure determination of both soluble and integral membrane proteins. We also developed extensive experience in software development. The lab research programs span structural bioinformatics, protein expression and purification, X-ray crystallography, small-angle X-ray scattering (SAXS), and protein NMR with applications in cancer biology, virology, de novo protein design, integral membrane proteins, and drug development.