The Biochemistry & Biophysics (BCBP) graduate program includes a broad grounding in the mathematical, chemical, physical, and biological sciences.

In addition to satisfying Institute requirements for the Ph.D. degree, entering students must either complete the Molecular Biochemistry I course (BCBP 4760), or have had the equivalent as part of their previous education. Students must complete graduate versions of three of the Molecular Biophysics Module courses. Additional courses may be chosen relevant to the area of specialization of each student's research.

The Doctor of Philosophy degree in BCBP requires a dissertation based on an original research project. Entering students must undertake two research rotations during the first year of study. These research rotations must be carried out with faculty members selected from the list of participating faculty. The two faculty members selected to direct these research rotations must be based in two different departments. After completing two research rotations, a thesis adviser must be chosen from the list of participating faculty by the end of the second semester. A seminar must be presented, and a candidacy exam completed, by the end of the second year of study.