Jesse was a founding partner of Domain and became partner emeritus in 2018. He has been a director of 38 early-stage healthcare companies, 23 of which have become successful public companies. He has been a founder, president, and chairman of numerous venture-stage companies. Before the formation of Domain, Jesse was vice president of the predecessor organization to The Wilkerson Group and its venture capital arm, C.W. Ventures. While at C.W. Ventures, he served as president and CEO of Microsonics, a pioneer in computer image processing for cardiology. Before that, Jesse held executive positions at Technicon Instruments (now Siemens Medical Solutions Diagnostics), and at G.E. He received his B.S. in physics from Rensselaer Polytechnic Institute and his M.A. and PhD in physics from Princeton University.