Leo Q. Wan

Leo Q. Wan

Associate Professor Biomedical Engineering

Leo received both B.S. and M. Eng. degrees in Mechanical Engineering from the University of Science and Technology of China (USTC), and a PhD in Biomedical Engineering from Columbia University, where he became a post-doc on stem cells and tissue engineering. He joined the Biomedical Engineering Department at the Rensselaer Polytechnic Institute as an assistant professor in 2011, and became an associate professor in 2016.

Leo's research is focused on developing novel strategies for tissue regeneration/repair, and establishing innovative organ-on-a-chip devices for disease diagnosis and drug screening. His lab unitizes interdisciplinary approaches including micro-/nanofabrication, stem cells, tissue engineering, biomaterial, cell/tissue biomechanics, and bioimaging.

Leo is a Pew scholar (Class 2013), and recipient of NIH Director's New Innovator Award, National Science Foundation Early Career Award, American Heart Association Scientist Development Grant, and the March of Dimes Basil O’Connor Starter Scholar Research Award.

  • Ph.D. in Biomedical Engineering, Columbia University 2007

    M.Eng. in Fluid Mechanics, University of Science and Technology of China (USTC) 2001

    B.S. in Theoretical and Applied Mechanics, University of Science and Technology of China (USTC) 1998

  • MJ Raymond, P Ray, G Kaur, P Haynes, M Fredericks, AV Singh, and LQ Wan, Multiaxial Polarity Determines Individual Cellular and Nuclear Chirality, submitted.
  • AE Abu-Hakmeh, A Kung, B Mintz, S Kamal, J Cooper, LX Lu, LQ Wan*, Sequential Gelation of Tyramine Substituted Hyaluronic Acid Hydrogels Enhances Mechanical Integrity and Cell Viability, in revision.
  • MJ Raymond, P Ray, G Kaur, AV Singh, and LQ Wan, Cellular and Nuclear Alignment Analysis for Determining Epithelial Cell Chirality, Annals of Biomedical Engineering, epub ahead of print, doi: 10.1007/s10439-015-1431-3.
  • X Chen, Y Zhou, BK Zimmerman, L Wang, MH Santare, LQ Wan, and XL Lu, Determining Tension-Compression Nonlinear Mechanical Properties of Articular Cartilage from Indentation Testing. Annals of Biomedical Engineering, epub ahead of print, doi:10. 1007/ s10439-015-1402-8.
  • AKM Fleck and LQ Wan, Magnetic Resonance Imaging of Healthy, Diseased, and Regenerated Cartilage, Current Tissue Engineering, epub ahead of print, doi: 10.2174/2211542004666150713184556.
  • Y Zhou, MA David, X Chen, LQ Wan, RL Duncan, L Wang and XL Lu, 2015. Effects of Osmolarity on the Spontaneous Calcium Signaling of In Situ Juvenile and Adult Articular Chondrocytes. Annals of Biomedical Engineering, epub ahead of print, doi: 10.1007/s10439-015-1406-4.
  • J Xie, T Owen, K Xia, AV Singh$, E Tou, B Arduini, H Li, LQ Wan, B Callahan, and C Wang, 2015. Zinc Inhibits Hedgehog Autoprocessing: Linking Zinc Deficiency with Hedgehog Activation, Journal of Biological Chemistry, 290(18), pp.11591-600.
  • KE Worley, D Shieh, and LQ Wan, 2015. Inhibition of Cell-Cell Adhesion Impairs Epithelial Chiral Morphogenesis on Micropatterned surfaces, Integrative Biology, 7(5), pp. 580-90.
  • AV Singh, M Raymond, F Pace, A Certo, JM Zuidema, CA McKay, RJ Gilbert, XL Lu, and LQ Wan*, 2015. Astrocytes Increase ATP Exocytosis Mediated Calcium Signaling in Response to Microgroove Structures, Scientific Reports, 5: 7848.
  • S Bhumiratana, RE Eton, SR Oungoulian, LQ Wan, GA Ateshian, and G Vunjak-Novakovic, 2014. Large, Stratified, and Mechanically Functional Human Cartilage Grown in vitro by Mesenchymal Condensation, Proceedings of National Academy of Science, 111(19), pp. 6940-5.