Keith Fraser

Keith Fraser

Dr. Fraser's research interests are broadly in the area of computational biology and how in silico models can be developed to advance our understanding of a range of biochemical mechanisms. These include protein folding, protein ligand interactions and drug toxicity.

  • Ph.D. Biology, (Rensselaer Polytechnic Institute), M.S. Biology, (St. John's University), B.S. Biology (St. John's University)

  • Ren, S; Fraser, K; Kuo, L; Chauhan, N; Adrian, AT; Zhang, F; Linhardt, RJ; Kwon, PS; Wang, X. Designer DNA nanostructures for viral inhibition. Nature Protocols (2022)
  • Badri, A; Williams, A; Awofiranye, A; Datta, P; Xia, K; He, W; Fraser, K; Dordick, JS; Linhardt, RJ; Koffas, MAG. Complete biosynthesis of a sulfated chondroitin in Escherichia coli. Nature Communications 12, 1389 (2021)
  • Kwon, PS; Oh, H; Kwon, SJ; Jin, W; Zhang, F; Fraser, K; Hong, JJ; Linhardt, RJ; Dordick, JS. Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro. Cell Discovery, 6, 50 (2020)
  • Kwon, PS; Ren, S; Kwon, SJ, Kizer, M; Kuo, L; Zhou, F; Zhang, F; Kim, D; Fraser, K; Kramer, LD; Seeman, NC; Dordick, JS; Linhardt, RJ; Chao, J; Wang, X. Designer DNA architecture offers precise and multivalent spatial pattern recognition for viral sensing and inhibition. Nature Chemistry, 12, 26-35 (2020)
  • Kim, D; Kwon, SJ; Sauve, J; Fraser, K; Kemp, L; Lee, I; Nam, J; Kim, J; Dordick, JS. Modular Assembly of Unique Chimeric Lytic Enzymes on a Protein Scaffold Possessing Anti-Staphylococcal Activity. Biomacromolecules, 2019, 20, 10, 4035-4043
  • Kizer, M; Huntress, ID; Walcott, BD; Fraser, K; Bystroff, C.; Wang, X. The complex between a multi-crossover DNA nanostructure, PX-DNA, and T7 endonuclease I. Biochemistry, 2019, 58, 10, 1332-1342
  • Wu, X; Fraser, K; Zha, J; Dordick, JS. Flexible Peptide Linkers Enhance the Antimicrobial Activity of Surface Immobilized Bacteriolytic Enzymes. ACS Appl. Mater. Interfaces, 2018, 10 (43), pp 36746-36756
  • Fraser, K; Bruckner, D.M; Dordick, JS. Advancing Predictive Hepatotoxicity at the Intersection of Experimental in Silico, and Artificial Intelligence Technologies. Chem. Res. Toxicol., 2018, 31 (6), pp 412-430
  • Kim, SY; Zhao, J; Liu, Z; Fraser, K; Lin, L; Zhang, X; Zhang, F; Dordick, JS; Linhardt, R.J. Interaction of Zika Virus Envelope Protein with Glycosaminoglycans. Biochemistry, 2017, 56 (8), pp 1151-1162
  • Rosenman, D.J; Huang, Y-M; Xia, K; Fraser, K; Jones, V.E; Lamberson, C.M; Van Roey, P; Colón, W; Bystroff, C. Green-lighting green fluorescent protein: Faster and more efficient folding by eliminating a cis-trans peptide isomerization event. Protein Science, 2014, vol 23:400-410