Director, Biochemistry and Biophysics Graduate Program
Professor Wang's research focuses on the application of nuclear magnetic resonance (NMR) spectroscopy to study Alzheimer's disease and other significant problems in neuroscience and aging. In addition, he studies protein autoprocessing such as intein-mediated protein splicing and Hedgehog autoprocessing in physiology and diseases. NMR spectroscopy provides a powerful modern analytic technique for understanding the structure and function of biological molecules, such as proteins and nucleic acids.
MD, Peking Union Medical College, 1996; PhD, Biochemistry and Molecular Genetics, Cornell University, 2000
- Wen Chen, Eric Gamache, David Rosenman, Jian Xie, Maria Lopez, Yueming Li, and Chunyu Wang (2014). “Familial Alzheimer's Mutations within APPTM Increase Abeta42 Production by Enhancing the Accessibility of the Epsilon-Cleavage Site”. Nature Communications 4:3037 doi: 10.1038/ncomms4037.
- Connors, Christopher Ryan, David Jacob Rosenman, Dahabada HJ Lopes, Shivina Mittal, Gal Bitan, Mirco Sorci, Georges Belfort, Angel E. Garcia, and Chunyu Wang (2013). “Tranilast Binds to Aβ Monomers and Promotes Aβ Fibrillation.” Biochemistry 52(23): 3995-4002
- David J Rosenman, Christopher Connors, Wen Chen, Chunyu Wang, Angel E. Garcia, (2013). “Monomers Transiently Sample Oligomer and Fibril-like Configurations: Ensemble Characterization Using a Combined MD/NMR Approach” Journal of Molecular Biology 425(18): 3338-3359.
- Wen Chen, Lingyun Li, Zhenming Du, Jiajing Liu, Julie N. Reitter, Kenneth V. Mills, Robert J. Linhardt, and Chunyu Wang (2012). “Intramolecular Disulfide Bond between Catalytic Cysteines in an Intein Precursor” Journal of the American Chemical Society. 134(5):2500-2503.
- Zhenming Du, Jiajing Liu, Clayton D. Albracht, Alice Hsu, Wen Chen, Michelle D. Marieni, Kathryn M. Colelli, Jennie E. Williams, Julie N. Reitter, Kenneth V. Mills, Chunyu Wang (2011). “Structural and Mutational Studies of a Hyperthermophilic Intein from DNA Polymerase II of Pyrococcus abyssi”, Journal of Biological Chemistry, 286: 38638-38648. With a cover illustration of Nov. 4, 2011 issue of JBC.
- Sinha, Sharmistha; Lopes, Dahabada; Du, Zhenming; Pang, Eric; Shanmugam, Akila; Lomakin, Aleksey; Talbiersky, Peter; Tennstaedt, Annette; McDaniel, Kirsten; Bakshi, Reena; Kuo, Pei-Yi; Ehrmann, Michael; Benedek, George; Loo, Joseph; Klärner, Frank-Gerrit; Schrader, Thomas; Wang, Chunyu; Bitan, Gal (2011) “Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins”, Journal of the American Chemical Society 133(42): 16958-16969.
- Du, Z., Zheng, Y., Patterson, M., Liu, Y. and Wang, C. (2011) “pKa Coupling at Intein Active Site: Implications for Coordination Mechanism of Protein Splicing with a Conserved Aspartate”, Journal of the American Chemical Society 133:10275-10282.
- Alexey V. Gribenko, Mayank M. Patel, Jiajing Liu, Scott A. McCallum, Chunyu Wang, George I. Makhatadze (2009). “Rational Stabilization of Enzymes by Computational Redesign of Surface Charge-Charge Interactions.” Proceedings of the National Academy of Science. 106(8): 2601-2606.